Endocrine Abstracts

Case history: A male patient presented to the Endocrine clinic age 64, with an 18-year history of erectile dysfunction. He was treated under Urology with phosphodiesterase inhibitors and Nebido injections for hypogonadism. Notably the cause of hypogonadism had not been established. The patient was concurrently reviewed by Oral Medicine due to a 2.5-year history of xerostomia, and Dermatology for a non-healing, erythematous, pruritic lesion on his right lower leg and several wh...

Introduction: Obstructive sleep apnoea (OSA) is reported to have effects on a number of hormone systems including glycaemic control, catecholamines, and the HPA axis. In this study we aimed to determine the impact of OSA on IGF-I levels.Patients & Methods: This is a prospective cohort study performed at Leeds Teaching Hospitals. Patients were recruited from the Sleep Apnoea Clinic between November 2014 and May 2...

Introduction: Patients with acromegaly are often left with long-term sequelae, among which arthropathy is the most common. Studies have shown impaired quality of life (QoL) in patients with acromegaly, even after long-term remission. Arthropathy is a negative predictive factor of QoL, due to its impact on physical symptoms and functioning.Patients/Methods: To characterise further the extent of the acromegalic arthop...

Introduction: Obstructive sleep apnoea (OSA) is reported to have effects on a number of hormone systems including glycaemic control, catecholamines, and the HPA axis. In this study we aimed to determine the impact of OSA on IGF-I levels.Patients & Methods: This is a prospective cohort study performed at Leeds Teaching Hospitals. Patients were recruited from the Sleep Apnoea Clinic between November 2014 and May 2...

Introduction: Patients with acromegaly are often left with long-term sequelae, among which arthropathy is the most common. Studies have shown impaired quality of life (QoL) in patients with acromegaly, even after long-term remission. Arthropathy is a negative predictive factor of QoL, due to its impact on physical symptoms and functioning.Patients/Methods: To characterise further the extent of the acromegalic arthop...

Introduction: Ipilimumab is a human monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4 (CTLA-4) that has been shown to significantly improve survival in patients with metastatic melanoma. Immune-related adverse events (irAEs) occur in some patients with increased T-cell activation, of which ipilimumab-related hypophysitis (IH) is an important treatment complication. The aim of this study is to determine the incidence of IH and characterise clinical presentat...

Introduction: Checkpoint inhibitors (CPi) are finding a place in the treatment algorithm of an increasing number of cancers. Immune-related (ir) endocrinopathies are frequent side-effects. Diabetes mellitus (irDM) is infrequent, but often presents acutely and can be potentially life-threatening There are ˜60–70 cases characterising irDM in the literature. We describe 4 cases of irDM to add to the understanding of this condition. All four patients were undergoing trea...

Introduction: PATRO Adults is an ongoing, longitudinal, noninterventional study assessing the long-term safety and efficacy of Omnitrope® (Sandoz; recombinant human growth hormone [rhGH]), among adults with severe growth hormone deficiency (GHD) treated in routine clinical practice in European countries. Omnitrope® was approved by the European Medicines Agency (EMA) in 2006, representing the first biosimilar approved by the EMA. We report the la...

Introduction: The daily maintenance dose of conventional hydrocortisone currently recommended by international guidelines for the management of primary adrenal insufficiency (PAI) or secondary adrenal insufficiency (SAI) is 15−25 mg/day, in 2−3 divided doses. The aim of this analysis was to investigate inter-country differences in glucocorticoid replacement doses in patients with PAI and SAI.Design: EU-AIR (ClinicalTrials.gov identifier: NCT0...

Introduction: If untreated, adrenal insufficiency (AI) leads to premature death. Hospital record data suggest mortality associated with primary (PAI) and secondary AI (SAI) to be 2–3-fold higher than in the general population. Major causes of death include cardiovascular disease, Addisonian crises, brain tumours and infections; however, there is little further characterization of patients who died.Design: We analysed real-world data from the Europea...